Sentence examples for by changing the affinity from inspiring English sources
By changing the affinity probe pairs this method could be easily expanded for other protein analytes, showing promising potential for point-of-care testing and extensive applications in bioanalysis.
Bellini et al (2010) reported that these polymorphisms are associated with differences in promoter activity by changing the affinity for distinct transcription factors.
To date, it has been observed that the FCRL3 −169T>C SNP affects the expression of FCRL3 by changing the affinity binding of nuclear factor-kappa B (NF-κB) to its promoter.
It is noticeable that the differences in Tc and TetA amounts that are caused by changing the affinity of Tc for TetR2 are larger than the differences that are caused by modifying the affinity of TetR2 for the operator sites.
It is known that Hb oxygen affinity can be modified by amino acid substitutions that decrease or enhance the structure for oxygen binding or by changing the affinity of Hb for allosteric effectors (Perutz 1989).
The ancestral T-allele at this site plays a protective role against hypercholesterolemia by changing the affinity of this region for transcription factors leading to an increase of 2.5 times in the transcriptional activity of the LDLR gene.
Therefore, we proposed that by changing the binding affinity of the fibroblast to collagen, integrins are causing the induction of intracellular ROS, which leads to oxidant stress and caspase-3 activation.
Nevertheless, it has been postulated that early release is important for the functionality of the reprotonation switch, as it ensures irreversibility of the M1 → M2 reaction by changing the proton affinity of Asp85.
Histamine (i) stimulated phosphoinositide hydrolysis (EC50 = 8.6 +/- 4.1 microM), (ii) activated protein kinase C (2.4-fold increase in activity), and (iii) increased phosphate uptake (EC50 = 3.2 +/- 1.8 microM) by increasing maximal transport (Vmax(basal) = 6.2 +/- 0.3 versus Vmax histamine) = 9.1 +/- 0.4) without changing the affinity of the transport process for phosphate.
These defects can exert their deleterious impact through changing protein stability and causing the protein to be more susceptible for degradation; changing the protein's functional site residues; or changing the affinity controlling protein-protein interactions [ 10].
FXYDs modulate the holo-enzyme kinetic properties of Na+/K+-ATPase by changing the rate and affinity of Na+ and K+ transport (Garty and Karlish, 2006).
