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The increase in noradrenaline was not accompanied by changes in transcript levels of genes involved in monoamine metabolism.
In a previous study we have shown that acute exposure to ethanol results in altered transcript abundance levels of chemoreceptor and detoxification genes, whereas the subsequent development of tolerance is accompanied by changes in transcript abundances of metabolic enzymes [ 35].
Such indirect effects may manifest themselves by changes in transcript levels that could be studied by comparing the transcriptome (including small RNAs) of CLPG Mat /+ Pat with that of +/+ animals, and efforts towards that goal are in progress.
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In other words, almost all differences between splicing patterns associated with cis-sQTL are caused by changes in transcripts expressed from natural alleles.
We next investigated if this total block in protein synthesis was caused by changes in RNA transcript stabilities or a global transcription arrest in the stalled T. brucei VG1.1 cells.
To identify biological functions potentially affected by the changes in transcript levels, DEGs were submitted to the Database for Annotation, Visualization and Integrated Discovery (DAVID, [ 27, 28]).
Thereafter, we evaluated the model predictions against available gene expression data by comparing changes in transcript levels (converted into a Boolean form) with simulations of the logical steady state of the model.
In plants the response to abiotic stress is modulated by changes in ethylene receptor transcript levels, suggesting that the observed changes in ethylene receptor transcripts levels serve similar function in K. crenulatum.
The metabolic normalization was also indicated by reductions in circulating levels of insulin and leptin, and by changes in the metabolic transcript profile in liver.
During continuous growth in specific chemostat cultures, budding yeast undergo robust oscillations in oxygen consumption that are accompanied by highly periodic changes in transcript abundance of a majority of genes, in a phenomenon called the Yeast Metabolic Cycle (YMC).
Changes in gene transcripts were accompanied by changes in expression of transcription factors, especially those in the WRKY family of transcription factors.
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