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It is not believed that the observed protein turnover is driven by changes in systemic hormones as we (Table 2) and others [13], [28] have not been able to show changes in a range of potent hormones except from insulin, which previously has been found to be increased after hypoxic exposure [28].
It is hypothesized that the insulin sensitizing effects of PPARδ activation are brought about by changes in systemic metabolism.
The increase in urine output was predicted by changes in RI but not by changes in systemic hemodynamics.
In contrast, other studies, investigating an earlier PiCCO algorithm, showed an impairment of pulse contour analysis by changes in systemic vascular resistance [ 24].
Therefore, our data do not support the possibility that the increase in MFI observed was induced by changes in systemic hemodynamics.
Furthermore, treatment eras are not identical to treatment groups and not all of the reported patients were affected by changes in systemic chemotherapy.
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Consequently, our results suggest that the increased mortality seen with HES in the 6S trial was not mediated by early changes in systemic inflammation.
We therefore concluded that the beneficial hemodynamic changes observed with empagliflozin were unlikely to be influenced by concomitant changes in systemic RAAS and NO activity.
By extension, the contralateral joint may be susceptible to developing OA caused by changes in gait or systemic effects.
However, RBF and DO2 were not influenced by the mild changes in systemic blood pressure.
We hypothesized that in patients with septic shock passive movements might be harmful by inducing significant changes in systemic hemodynamics.
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