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Contributing factors pertain to (1) reduced interaction of neutrophil granulocytes with brain endothelial cells linked to reduced circulating leptin levels and (2) an attenuated inflammatory response of the brain as reflected by changes in several inflammatory markers including inflammatory transcriptions factors namely NF-IL6.

Taken together, these findings suggest sex-specific involvement of Y2 receptors on NPY-expressing neurons in the regulation of energy metabolism, particularly adiposity, which could be mediated by changes in several key enzymes involved in lipolysis and lipogenesis in liver and skeletal muscle.

This state is reflected by changes in several parameters of cellular metabolism, such as inhibition of gluconeogenesis and ketogenesis [ 12– 16].

Additionally, prenatal exposure to BDE-47 in rats affected body weight in both male and female offspring which was accompanied by changes in several key processes in glucose homeostasis and fat metabolism exclusively for males.

Finally, ecosystems provide us with medical and genetic resources, which are necessary to prevent or cure diseases [ 41]. Figure 3 shows that the impact of globalisation on each proximal health determinant is mediated by changes in several distal factors.

Effectiveness was measured by changes in several biochemical tests for blood obtained at 3 time points: during the 30 days prior to starting the combined study therapies (baseline assessment), and at the 6-month (±1) and 12-month (±1) follow-up visits.

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The last deglaciation that commenced by 19,600 cal yr BP is characterized by gradual changes in several sediment physical and geochemical proxies, including increasing C/N ratios and terrestrial productivity, decreasing magnetic susceptibility and clastic sediment flux, along with rising and relatively higher lake-levels.

So a situation in which the 3-dose strategy would become superior to the 2-dose strategy may be achieved by a large change in one parameter alone, or by smaller changes in several parameters in combination.

CBF-V rose when Tcore was lowered by an external system in healthy volunteers; this might be explained by concomitant changes in several other parameters, like arterial carbon dioxide partial pressure, which is the most widely investigated factor that influences CBF-V [ 15].

We showed how climate change effects on streamflow propagate from high elevation headwater catchments to the river in the main valley by analyzing changes in several hydrological metrics and at various temporal scales across 297 control sections.

Insulin resistance in hypertensive Dahl S rats is manifested by significant changes in several parameters compared to Dahl R rats.

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