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When the size distribution of the intestinal polyps was examined, the number of smaller polyps appeared to be more significantly affected by changes in oxygen exposure (Figure 3B).
The molecular and cellular events induced by changes in oxygen levels are very broad in eukaryotes.
HIF-1β is constitutively expressed, whereas HIF-1α is tightly regulated by changes in oxygen regimes [ 5, 6].
The value of ScvO2 is determined by changes in oxygen delivery and consumption, both of which are subject to considerable variation during the peri-operative period [ 4].
Such epigenetic modifications may be imposed on a tumor cell by microenvironmental pressure, such as provided by changes in oxygen levels, metabolites, or interactions with non-tumor cells.
Changes in oxygen demand will therefore only be compensated by changes in oxygen extraction in the same direction and indicated by inverse changes in venous oxygen saturations.
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The nitrification rate was likely affected by changes in dissolved oxygen and potentially manganese.
The HIF pathway is activated by changes in cellular oxygen levels and has significant impacts on the regulation of gene expression patterns in cancer cells.
The mechanisms by which changes in oxygen tension are sensed and converted into downstream signals that lead to vasomotor responses is known as oxygen sensing.
Studies using SLO also suggest that changes in blood flow in the retina are paralleled by matched changes in oxygen content [ 41].
Raichle et al. (2001; Raichle and Snyder 2007) pointed out that task-induced changes in blood flow are accompanied by smaller changes in oxygen consumption (Fox and Raichle 1986).
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by changes in blood
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by differences in oxygen
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