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Many of these effects, such as neurite outgrowth and increased dendritic spine density, are mediated by changes in neuronal cytoskeletal architecture.
The amount of deoxyhemoglobin is modulated locally by changes in neuronal activity, blood flow and oxygen consumption and is, therefore, used as a marker of brain activity.
Dietary RS significantly impacts on adipose tissue patterning, adipocyte morphology and metabolism, glucose and insulin metabolism, as well as affecting appetite regulation, supported by changes in neuronal activity in hypothalamic appetite regulation centres which are suggestive of satiation.
These results indicate that the groups showed significant differences in NT receptors expression levels that were not influenced by changes in neuronal densities.
This adaptive process was paralleled by changes in neuronal responses in the primary auditory cortex, which became relatively more sensitive to these monaural spatial cues.
Furthermore, there is evidence in the literature that Camk1g mRNA expression is regulated by changes in neuronal firing patterns similar to IEGs.
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Although primary changes in cerebral blood flow do not directly alter rates of cerebral metabolism, changes in regional brain perfusion detected by water PET are thought to be driven by regional changes in neuronal activation and their associated regional changes in cerebral metabolism and thus form a surrogate marker of neuronal activation.
Finally, using tetrodotoxin to silence network activity, as well as exposure to a selective α7-nAChR agonist or antagonist, we observed that α7-nAChRs cell surface dynamics is modulated by chronic changes in neuronal activity.
Correspondingly, one would expect patients to reflect this reduction in attenuation by presenting changes in neuronal activation related to sensory feedback.
AMPA receptor expression at synapses is regulated to modify synaptic efficacy in the context of long-term potentiation (LTP) and long-term depression (LTD) (Song and Huganir, 2002), as well as homeostatic control of synaptic function driven by persistent changes in neuronal activity (Turrigiano, 2008).
The network reverberation hypothesis is bolstered by the finding that the goldfish oculomotor integrator during normal saccadic movements could not be reproduced by saccade-like changes in neuronal firing induced by intracellular current injection, suggesting that the integrator effect is dependent on persistent changes in synaptic inputs [ 150].
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