Sentence examples for by changes in histone from inspiring English sources
Transcriptional activation by steroid hormone receptors is accompanied by changes in histone and non-histone protein post-translational modification (PTM) that result from the enzymatic activity of coactivator and corepressor proteins such as GRIP1 and CARM1.
Changes in the way that the 3' end affects mRNA processing, localization, or translation of histone mRNA could be reflected by changes in histone protein abundance or stoichiometry that alter properties of chromatin due to misregulation of chromatin assembly.
Following ligand binding, transcription by steroid receptors is initiated by receptor-DNA binding and changes in chromatin structure contributed to by changes in histone post-translational modifications (PTMs) [12].
Activation and repression of transcription is accompanied by changes in histone PTMs and such modifications occur at the MMTV promoter on both histones H3 and H4 [26] [286]–[28].
These findings suggested that Cyc8 Tup1 repression activity is modulated by changes in histone acetylation.
There is significant evidence from other systems that the diurnal and circadian regulation of transcription is controlled by changes in histone acetylation.
Recent research on the architecture of the interphase nucleus and chromatin remodeling, mediated primarily by changes in histones, has prospected the era of epigenetics and epigenomics.
These results indicate that the up-regulation of p21 in LSD1-null cells was not directly mediated by changes in the histone targets of LSD1.
ChIP Seq analysis has also been used to comprehensively assess chromatin status by monitoring changes in histone modification patterns.
Furthermore, our findings suggest that key developmental miRNAs are regulated by global changes in histone modification, thus linking the mammary epigenome with genome-wide changes in the expression of genes and miRNAs.
As the PPARγ ChIP did not appear to support the competitive binding model, we next used ChIP to examine the MMP-1 and MMP-13 promoters for evidence of nuclear receptor-associated coactivator and corepressor activity by detecting changes in histone acetylation.
