However, administrative data may be affected by changes in coding practices that distort incidence and mortality estimates.
Any improvement in mortality among DNR patients due to the RRT would not be reflected by changes in code-related deaths, as DNR patients were explicitly excluded from the cardiopulmonary-arrest code response.
Possible explanations for the observed regional variations are different coding preferences, further influenced by changes in coding and reimbursement rules.
The large increases in SIDS rates in the years 1968 1971 and 1971 1974 were most likely caused by changes in coding.
Eukaryotic genomes have large numbers of duplicated genes that can evolve new functions or expression patterns by changes in coding and regulatory sequences, referred to as neofunctionalization.
Since the ANZICS definition of AKI remained constant, their results are less likely to be affected by changes in coding practices over time.
From 1994, incidence, prevalence, and hospitalization rates decreased for men and women younger than 45 years and increased in the older population, although the latter finding might be partly explained by changes in coding practice.
Outcomes, and some maternal and obstetric characteristics, were obtained from hospital records within the most recent 5-year period (April 2002 March 2007), in order to ensure that their measurement was the same for all of the study subjects, and not affected by secular trends in the outcomes or by changes in coding schemes and reporting practices over time.
This increase in cerebral lymphoma is not adequately explained by improvements in the precision of diagnosis or by changes in disease coding or cancer registration practice.
Muscle phenotype divergence was found to be regulated by the divergence of coexpression network modules under artificial selection, and not by changes in the coding sequence of genes.
A prominent view in this field is that morphological diversity is caused primarily by mutations in the cis-regulatory regions of genes [ 40], rather than by changes in protein coding sequences as suggested by other authors (eg [ 41]).
