Sentence examples for by changes in binding from inspiring English sources

Such cases are generally thought to be the exception rather than the rule, and the paradigm remains that changes in a single protein trans-factor are not feasible in cases where the downstream effects, such as those induced by changes in binding specificity, are widespread across loci and biological function (Peter and Davidson 2011).

Without seeing such an alignment is hard to accept that the rigidity of the binding-site is not affected by changes in binding-site sequence.

Manipulation of the (distal) heme cavity architecture is often reflected by changes in both binding rates as well as in the strength of binding of cyanide to the ferric heme iron.

On the contrary, we showed that the ATP-based excision of the mutant enzymes was slightly decreased with respect to WT RT, possibly because of decreased affinity of the mutant enzymes for the ATP excision substrate, incurred by changes in the binding environment of ATP, such as the loss of lysine at position 70.

In this manner, those genes directly affected by changes in HP1β binding were readily determined.

This is the central argument that these changes in CaV2 function are caused by changes in Munc13-1 binding to the synprint site.

This is the central argument that these changes in Ca V 2 function are caused by changes in Munc13-1 binding to the synprint site.

Mercury retention may be influenced by changes in mercury binding by functional enzymes and proteins that transport, oxidize, and reduce mercury and its metabolites in humans (Gundacker et al. 2010).

The binding of ubiquitously expressed factors may be to a large extent invariant and the effect of crippling their activity on development may be dictated by tissue-specific factors or by changes in their binding during development.

This regulation is mediated by the changes in binding of stabilizing trans-acting factors, AUF1 and Unr, and the destabilizing protein KSRP, to the defined cis-acting ARE in the PTH mRNA 3'-UTR [ 16, 18- 20].

Environmental perturbations can also be complicated by time-dependent changes in binding and expression.