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Furthermore, some studies have demonstrated that apoptosis induced by TRAIL could be modulated by cellular levels of AKT [24], an active member of the EGF pathway.
The results indicate that there may be extensive crosstalk between MAPK signaling and signaling pathways that are regulated by cellular levels of PIs or IPs.
The ratio of proteasomes can also be regulated by cellular levels of NADH, a co-enzyme that directly binds 19S subunits and influences 26S proteasome stability (Tsvetkov et al., 2014).
Recently, several in vitro studies have shown that the golli myelin basic proteins regulate Ca2+ homoeostasis in OPCs (oligodendrocyte precursor cells) and immature OLs (oligodendrocytes), and that a number of the functions of these cells are affected by cellular levels of the golli proteins.
In T cells, PKB/Akt activity is controlled directly by Ag receptors/costimulatory molecules and or cytokines and the level of Akt activity is determined by cellular levels of Phosphatidyinositol (3,4,5) tris phosphate and the activity of PDK1 and mTOR (mammalian target of rapamycin) 51.
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Nicotinamide partly or completely abrogates yeast lifespan extension by CR, possibly by increasing cellular levels of NADH, a competitive inhibitor of the Sir2 protein [41], [42].
This effect paralleled inhibition of hydroxymethylglutaryl (HMG -CoA reductase and was prevented by mevalonate and polyisoprenoid dipHMG -CoAs, suggesting that statins induce autophagy by depleting cellulareductaseof gerandlgeranyl diphosphate (25).
This suggests that Plk1 controls Aurora A localization and function by regulating cellular levels of hBora.
Its xanthine-mediated O2 – generation is regulated by the cellular levels of NAD(H) and the cellular redox state.
A variety of important anticancer drugs kill cells by increasing cellular levels of topoisomerase II-DNA cleavage complex [ 16].
A previous study has demonstrated that hypo-osmotic stress can regulate p75NTR by increasing cellular levels of Sp1 in primary cortical neurons (Ramos et al., 2007).
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