Only the fully human fusion protein was not trapped by cellular components at concentrations as low as 0.2 μg/ml, thus facilitating its extravasation from blood vessels and its disease-targeting activity.
For example, the genome of the closely related fungus Mycosphaerella graminicola is predicted to contain 11 12,000 genes, but to date, only ~30% have been annotated as to biological process, ~15% by cellular component, and ~40% by molecular function.
Autophagy or 'self- eating' is the process by which cells degrade their own cellular components to survive during starvation or to eliminate damaged organelles after oxidative stress.
Similar distribution pattern of GO classification was distinguished among three tissues, with the majority of the GO terms being assigned to biological process distributed in 21 subcategories (∼49%), followed by cellular component in eight subcategories (∼31%) and molecular function in 12 subcategories (∼20%).
The 'Biological Process' category occupied the largest proportion (25 terms), followed by 'Cellular Component' (18 terms) category and 'Molecular Function' category (14 terms) (Fig. 2; Additional file 1: Table S2).
Then genes were classified by cellular component which includes sub-cellular structures, locations and macromolecular complexes.
The biological process was the dominant category, which made up of 49.57%, followed by cellular component (35.45%), and molecular function (14.99%) (Additional file 1: Figure S1).
Biological processes comprised the majority of the functional terms (259,327; 47.40 %), followed by cellular component (151,379; 27.67 %) and molecular functions (136,326; 24.92 %).
In both ecotypes, the majority of GO terms describe molecular function (36% of unique transcripts), followed by cellular component (34%) and biological process (29%).
