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Expression of the various isoforms is tightly regulated by cell type and state of activation.
Thus, the effects of DAC inhibitors are diverse and incompletely understood, and likely vary by cell type and context.
The functions of JNK1 and JNK2 are determined by cell type and by the nature of the stress responsible for their activation.
ALT-PTK6 expression does not appear to be restricted by cell type, and is expressed in breast [46], prostate, and colon tumor cell lines (Figure 1B).
From such studies it is becoming clear that different apoptotic programs are induced by different stimuli and are governed by cell type and physiological context [30].
Although our present results clearly demonstrated NADPH oxidase impacts on endothelial dependent vasculature function, future work to more clearly examine diabetic induced changes in NADPH oxidase by cell type and subcellular local are warranted.
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Since TS is determined by cell types and amount of tissue, theoretically, SWE can be used to analyze cell types and level.
Although confirmed in squamous cell carcinoma of the esophagus [ 24], the relationship between miRNA and its target gene is affected by cell types and cell microenvironment; thus the same miRNA may play different roles in different cells [ 13].
To obtain a clearer representation of how CA04-induced gene expression influences different immune cell sub-types, we categorized enrichment by cell-type and function and employed a heat map to show how the enrichment was distributed in relation to time (summarized in Figure 3; see also Additional files 7 and 8 for a detailed heat map).
These receptors may coexist in a given cell, with relative abundance and activation status varying by cell type, tissue type, and physiologic or pathologic conditions.
These genomic comparisons highlight some commonalities in the transcriptional changes induced by arsenic and cadmium exposure, but the larger lack of overlap suggests that different transcriptional responses are likely influenced by cell type, organism, and dose.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com