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Instead, regulation is achieved by cell surface modulation events that alter N-CAM affinity, prevalence, mobility, and distribution on the surface.
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It has been proposed that cell-cell recognition occurs by means of local cell surface modulation of a small number of proteins rather than by expression of large numbers of different cell surface markers.
Similarly, cell surface modulation of Kit expression was also detected by flow cytometry analysis with a Kit-specific MFI higher in cells grown with SCF alone than in cells expanded with Epo+SCF (Figure 2B).
The cell surface properties of demulsifying bacteria cells can be controlled by cell surface substances.
It has been shown that single-dose radiation can induce immunogenic modulation that is characterised by cell-surface phenotypic changes leading to augmented tumour cell/cytotoxic T-cell interaction.
Modulation of cell surface targets by viruses may enhance viral replication directly, in a cell-autonomous fashion, or indirectly, through effects on non-infected cells or the immune response.
Retinoids are very well known to influence a variety of cellular processes, such as cellular growth and differentiation, cell surface alterations, and immune modulation.
Down modulation of cell surface CXCR4 needed by X4 HIV-1 to enter the cell is therefore another possible mechanism of inhibition of X4 HIV-1 by defensins.
The transport of pigment organelles during aggregation and dispersion is regulated by signaling mechanisms initiated by the binding of specific hormones to cell surface receptors, which results in the modulation of cAMP concentrations [4], [5].
Flow cytometry analysis showed no significant differences in the modulation of cell surface expression of 5T4 molecules after 2 or 24 hours by P1C9 and B1C3 mAbs as assessed in B16m5T4 cells (data not shown).
For comparative purposes, the modulation of the cell surface expression of MICL by soluble agonists was also examined.
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