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It is known that expression of DNA repair genes can be regulated by cell cycle regulators and that GC B cells are undergoing extensive cell proliferation.
It is not clear from these data however, whether the dispersal of CTPsyn is regulated by cell cycle regulators acting on CTPsyn itself (e.g. by phosphorylation) or through changes in concentrations of allosteric regulators previously shown to effect cytoophidium formation.
Resistance potential could be executed by cell cycle regulators such as cyclin D1, cdk1, Rb, p16, p27 and p53, one of the most important players capable of arresting cell cycle or triggering apoptosis.
The exact mechanism underlying neuroplastic processes mediated by cell cycle regulators in post-mitotic neurons remains to be determined.
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Thus, cell size can be altered by some cell cycle regulators, but is unaffected by others.
CCNA1 gene hypermethylation might hinder its antitumor function in regulating the cell apoptosis by binding cell cycle regulators like transcription factor E2F-1, Rb, and p21 family proteins as we mentioned before, which is thus related to the development of NSCLC, NPC, BCa, and HCC (http://www.i-md.com/docsearch/doc/edbe90ca-14a0-4780-8286-7fa6e0be1b51 dp=Respiratory) [ 5, 20, 21].
69, 73 TCF3 promotes survival of BL cells by activating B-cell receptor signaling and PI3K signaling pathways and by modulating cell cycle regulators such as CCND3, which is also mutated in BL (Fig. 1).
We hypothesized that continuous cyclic (over)stretching of the primitive airsacs would adversely affect proliferation of lung cells by influencing cell cycle regulators.
The molecular events during proliferation are tightly controlled by the cell cycle regulators.
Whereas the kinase signalling defects in the TUR leukemia cells are likely to be associated with the proliferative capacity, confirmative studies in colorectal cancer cells have demonstrated that high Erk activity can effect cell growth by targeting cell cycle regulators such as p27kip1 [ 10].
The finding that NUAK1 is controlled by critical cell cycle regulators namely CDKs, PLK1 as well as SCFβTrCP, that orchestrates ubiquitylation and degradation of key cell cycle co-ordinators [ 19], further highlights the role that NUAK1 is likely to play a major role in controlling cell cycle.
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