Sentence examples for by cell cycle checkpoints from inspiring English sources

The special chromatin modifications may be recognized as abnormal by cell cycle checkpoints and activate stress response pathway.

The cell cycle consists of four phases, G0/G1, S, G2, and M, which are tightly controlled by cell cycle checkpoints.

Cellular division is carefully monitored by cell cycle checkpoints, which are regulated by cyclins, cyclin-dependent kinases (CDK) and CDK inhibitors (Malumbres and Barbacid, 2001).

While some kinases, including PKA, C-TAK, and CAMKII have been shown to phosphorylate S287, they are not regulated by cell cycle checkpoints (Kiyokawa and Ray, 2008, Peng et al., 1998, Duckworth et al., 2002, Hutchins et al., 2003).

These findings are consistent with recent reports [ 39, 40] showing that the progression of early precancerous lesions (in the colon and elsewhere) is curbed by cell cycle checkpoints that are activated by DNA replication "stress".

The results in cell cycle redistribution were further confirmed by cell cycle checkpoint protein alteration.

To prevent and repair the DNA-damage, mammalian cells will control and stabilize the genome by cell cycle checkpoint.

These protein kinases can either directly or indirectly phosphorylate BRCA1 (by cell cycle checkpoint kinase 2 (Chk2) [ 42]).

Furthermore, we have also introduced a biological "apparatus", a virtual clock regulating cell cycles by cell-cycle checkpoints which function based on the number of DSBs produced.

Mutant p53 provides keratinocytes an advantage over normal keratinocytes in response to successive UVB exposure by evading cell cycle checkpoints and by allowing mutant keratinocytes to evade UVB-induced apoptosis.

For example, matrix metalloproteinases may act in transformation by inducing apoptosis in anchorage-dependent cells and/or by modifying cell cycle checkpoints through alterations in cell adhesion.