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Decongestants reduce secretions by causing vasoconstriction of the nasopharyngeal mucosa.
The rationale for this approach is to improve the markedly impaired circulatory function by causing vasoconstriction of the extremely dilated splanchnic vascular bed and by antagonizing effective hypovolemia so that MAP and renal perfusion can increase [ 22].
Renin release, and subsequent generation of local angiotensin II directly stimulates proximal tubular sodium reabsorption by activating sodium bicarbonate co-transporters and sodium hydrogen exchange [ 50] and also by causing vasoconstriction of the efferent renal arteriole, lowering peritubular hydrostatic pressure [ 51].
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The inhibition of endothelial nitric oxide synthase leads to the impairment of the microcirculation of the brain by causing vasoconstriction [ 1].
Third, inhibition of the pump in the vasculature might maintain or increase blood pressure by causing vasoconstriction either directly [ 25] or by effects on sympathetic innervation [ 26].
During cold temperatures, the signal from the brain causes vasoconstriction of the arterioles in the skin which allows the body to shift the blood to more vital areas of the body (Figure 3).
Hyperoxia can cause vasoconstriction of the carotid and downstream cerebral arteries.
Vasopressin causes vasoconstriction of skin, skeletal muscle, and splanchnic circulation, thus increasing peripheral arterial resistance [ 7].
Vascular tone is increased, causing vasoconstriction.
Mechanisms by which hyperoxia causes vasoconstriction include an inhibition of vasodilator (prostaglandins, nitric oxide) by reactive O2 species [ 43].
Coke is, of course, the legendary "boner killer," in that it causes vasoconstriction (the narrowing of blood cells), which leads to erectile dysfunction.
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