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Type I IFN suppresses tumors by causing expression of p53 and other tumor-suppressing agents [47].
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In gCJD, mutations in the PRNP gene predispose to disease [ 7, 8] by causing the expression of PrP protein with modified primary structure.
However, it may have a role in sensitising tumours to other anticancer therapies by causing re-expression of genes involved in drug sensitivity (Plumb et al, 2000).
Do spectrins have any effect caused by expression of Scrib C-terminus or the mutations in this region?
(E ) Learning is impaired by temporal knockdown of dnc in MB caused by expression of UAS-deGradFP at 28°C for 3 days.
Thus, these phenotypes observed in the R26floxneoWnt4; Col2a1-Cre mayants may be caused by overexpression of Wnt4, causing reduced expression of VEGF.
To test this hypothesis we asked if the phenotypes caused by expression of dVps4-DN are suppressed by concomitant reduction of JNK signalling.
Age‐dependent paralysis in a transgenic worm model of Huntington's disease caused by expression of aggregation‐prone Q35 was reduced by elc‐1 knockdown (Fig. 5B).
To date, over a hundred papers have shown that various pathological aspects of MNDs caused by expression of mutated genes can be modelled in the zebrafish.
These genes are also activated by c-Myc, as can be seen in murine T-cell lymphomas caused by expression of a tet-controllable Myc transgene [ 40].
It is now clear that DM is not caused by expression of a mutant protein.
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CEO of Professional Science Editing for Scientists @ prosciediting.com