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Doxorubicin induces renal injury by causing effacement of podocyte foot processes.
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Its deficiency causes effacement of podocyte foot processes, therefore it might be involved in the attachment of the podocyte to the GBM [ 60].
Magnetic resonance imaging (MRI) of the abdomen (Fig. 1) revealed a large retroperitoneal mass causing partial effacement of the IVC, and partial encasement of the aorta and superior mesenteric artery (SMA).
In contrast, administering shamporter + nephrin siRNA caused moderate effacement of foot processes (Figure 7.B).
Progression of amyloid deposition eventually causes complete effacement of the glomerular architecture.
EPEC adhere, and cause the local effacement of the microvilli of intestinal epithelial cells, giving raise to so-called attaching and effacing (A/E) lesions.
Other enteric pathogens such as enteropathogenic E. coli (EPEC) and Cryptosporidium cause other forms of mucosal disruption and modification characterized by effacement of enterocytes and pedestal formation [ 9, 10] or an unusual form of shallow invasion [ 11].
The evidence for specificity is further buttressed by the significant effacement of the reductive shift in cells lacking CRT.
The A/E histopathology is characterized by effacement of the brush border microvilli, intimate bacterial adherence to the enterocyte apical plasma membrane, and the accumulation of polymerized actin beneath the attached bacteria [ 70].
Another important virulence factor in EHEC is a pathogenicity island designated the locus of enterocyte effacement (LEE), which encodes proteins causing the formation of attaching and effacing (A/E) lesions on intestinal epithelial cells through actin rearrangement (2, 3).
Although G. destructans is not vasculotropic - that is, it does not directly invade blood vessels - effacement of the vasculature caused by this fungus could have the same effect of terminating blood flow to a region.
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