Sentence examples for by causing dissociation of from inspiring English sources

TNF-α also initiated NF-κB nuclear translocation by causing dissociation of IκB-α from NF-κB and by rapid degradation of IκB-α.

Although PGJ2 mimics the effect of some oxidative stressors by causing dissociation of 26S proteasomes, epoxomicin forms covalent adducts with the 20S proteasome active sites.

Aurora-A then promotes poly(A) elongation by phosphorylating CPEB, causing dissociation of the PUM2-CPEB-Maskin-eIF4E complex [18], [19], [20], [21].

The release of these key proteins can directly activate Bax by causing dissociation from its cytoplasmic anchor.

Of interest, in a recent report the extracellular matrix protein βig-h3/TGFBI was shown to increase vascular permeability in a Src-dependent manner by binding to αVβ5 and causing dissociation of VE-cadherin from endothelial junctions [49].

Another example is glycogen synthase kinase 3 (GSK-3), which has been proposed to inhibit anterograde transport by phosphorylating Kinesin light chain and thereby causing dissociation of membrane-bound organelles from KHC (Morfini et al., 2002).

Palomid 529 prevents angiogenesis by inhibiting the mammalian target of rapamycin (Akt/mTOR) signal transduction pathway and causing dissociation of rapamycin complexes, TORC1 and TORC2.

Moreover, inhibition of protein phosphatase 2A (PP2activityity by OA causes dissociation of PP2A from the microtubules (MTs) and destabilization of MT network, thus causing cytoskeleton destabilization (Tar et al., 2004).

In our previous studies, we have shown that RKIP pocket occupancy by the short-chain lipid, DHPE, causes dissociation of RKIP from Raf-1 [21].

However, the BDE153 congener did not cause dissociation of the binding by LCDPA, although it significantly suppressed TR action.

Kondo, S. et al. MUC1 induced by Epstein-Barr virus latent membrane protein 1 causes dissociation of the cell-matrix interaction and cellular invasiveness via STAT signaling.