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Chromosomal rearrangements without gene fusions have been implicated in leukemogenesis by causing deregulation of proto-oncogenes via relocation of cryptic regulatory DNA elements.
Oxidative stress is a causal factor and key promoter of a variety of cardiovascular diseases associated with apoptotic cell death by causing deregulation of related genes.
The aberrant activation of Rho-genes including those described in our study has been well-described in oncogenesis by causing deregulation of cell cycle progression and promoting cell proliferation [ 23].
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Important mutations that cause deregulation of representative breast cancer pathways reported by previous study have been captured by our approach.
These results suggest that inhibition of the ClpQY machinery caused deregulation of mitochondrial growth and functioning.
These results indicate that AβOs use a central route to cause deregulation of peripheral glucose homeostasis.
This suggests that MEKK1 induces apoptosis by causing a general deregulation of MAP kinase signaling rather than by the activation of a single pathway.
These abnormalities are most often caused by deregulation of mitochondrial proteins that make up the electron transport chain (ETC) complex, which is a major player in mitochondrial respiration [ 4].
Apparently, the typical leaf curl symptoms in N. benthamiana induced by co-infection of TYLCCNV and its betasatellite TYLCCNB could be caused by deregulation of those differentially accumulated miRNAs in responsive to betasatellite (Table 1).
4--The problems caused by deregulation of banks and other credit institutions.
Cancer is caused by deregulation of the cell cycle, enabling tumour cells to proliferate without limits.
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