Sentence examples for by causing conformational changes from inspiring English sources

Dithiothreitol (DTT) or MnCl2 have been shown to "activate" integrins by causing conformational changes of the integrin molecule [11].

The remaining three amino acids are accessible to solvent and can also interact with receptors on the T cell, being able to affect MHC binding affinity in several ways - through direct non-bonded interactions with the MHC, by causing conformational changes in anchor residues and by altering the dynamic properties of the whole peptide.

We conclude that there is no obligate role for furin cleavage in the activation of Notch1 by T-ALL-related NRR mutations, indicating that, as with ligand-mediated Notch activation, these mutations can activate signaling by causing conformational changes in the NRR, regardless of whether or not subunit dissociation can take place.

These data suggest that iron may control the interaction of TvACTN3 with actin or RNA possible by causing conformational changes by switching functions depending on the iron concentration but without modifying the amount of protein.

We hypothesize that phosphorylation of Ipr1 (induced in our screen by PMA) may mask its protease cleavage sites by causing conformational change and activation-induced protein complex formation (as shown previously)21, enabling GFP-Ipr1 translocation to the nucleus, where it dynamically associates with target chromatin via its SAND domain and nuclear matrix via its Sp100 domain.

The results suggest a model in which DNA uptake by TtPilF is powered by ATP hydrolysis, causing conformational changes in the C-terminal domains, which are transmitted via the stem to take up DNA into the cell.

It has been postulated that covalent modification by HNE causes conformational changes in the UCPs which allow the passage of protons back into the mitochondrial matrix [ 9].

First, we determined whether introduction of the β-marked (βm) gene, which is an artificially modified β-globin gene with part of its exon 2 replaced by equivalent Aγ-globin gene [9] (Fig. 1B), and flanking 5'HS5 by loxP sites per se caused conformational changes of the β-globin locus.

Next, we examined if the acid-amide substitution would cause conformational changes by using CD spectroscopy.

The intrinsic motions of proteins, determined by covalent and non-covalent forces, cause conformational changes with intermolecular and intercellular ramifications on signaling pathways, cell function, and physiological responses.

According to Sternberger et al. ALP either uncovers hidden epitopes by dephosphorylation, (Sternberger and Sternberger, 1983) causes conformational changes, or releases NfH from protein/organelle binding (i.e. binding to microtubules).