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It was proposed that these tannins exert their antibacterial effects by causing cell wall damage which eventually results in cell lysis [ 29].
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We have hypothesized that the cytokinesis defect caused by deletion of the MYO1 gene causes cell wall stress in addition to what may be a starved-state.
Overall, these data indicate that ranalexin caused cell wall stress similar to that produced by vancomycin - a cell wall active antibiotic.
His co-researcher, Bonn's Tanya Schneider, explained in a teleconference that teixobactin belongs to a new class of compounds and kills bacteria by causing their cell walls to break down.
That the addition of sorbitol restores cell growth without affecting the overall ubiquitylation level (Figs. 5 and 7C) indicates that the G1 defect of cdc48-3 is caused by cell wall defect, rather than the accumulation of denatured proteins per se.
We find that weak-walled pck2Δ cells are unable to establish and maintain cylindrical shape and, unexpectedly, form cytoplasmic protrusions apparently caused by cell wall rupture due to internal turgor pressure.
If the cell wall is weak, water pours in causing cells to swell and burst.
In this context, our cell wall-chemogenomic profiles clearly point to the importance of the V-ATPase function for withstanding the cell wall damage caused by different cell wall interfering-compounds.
For example, leaf divisions may have been caused by an insufficient cell wall formation, which led to the separation of the tissues of the leaf blade during its development.
The cracks on the leaf surface also seemed to be caused by a weakened cell wall.
The purification processes are challenging due to their large-scale factor and, thus, the affinity-matrix column purification systems cannot avoid clogging problems in the column caused by the plant cell wall debris being left over during biomass homogenization and removal processes [ 77].
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