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This suggests that MEKK1 induces apoptosis by causing a general deregulation of MAP kinase signaling rather than by the activation of a single pathway.
It remains to be determined whether aPPD alters raft resident proteins by causing a general alteration in the fluidity of the membrane, similar to other cholesterol derivatives, or whether the compound directly interacts with specific proteins in the lipid rafts to modulate their activity.
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As the mass of ice retreated far to the north, glacial rebound (uplift of the Earth's crust in response to removal of the loading by ice) caused a general tilting of the land surface; the new lake basins also contributed to the subsequent changes through their own erosional action.
Our work now extends this conclusion by the demonstration that ORMV infection causes a general enrichment of 20 21 nt RNAs irrespective of their origin.
To rule out that IPA exerts its IRE1 activating activity by causing general ER stress, we explored its effects on the two other branches of the UPR that signal through ATF6 and PERK.
While there is little information as to what spurred Cannon's kidney condition, Becker speculated that it could have been caused by a general illness that then affected his kidney function, or it could be related to medication he was taking.
All these data show, that the mitochondrial impairment in DJ-1 KO cells is not caused by a general mitochondrial dysfunction but by specific impairments of complex I-dependent oxidative phosphorylation in DJ-1 KO cells which can cause energetic depression of cell metabolism [16], [18].
KATMANDU, Nepal (AP) — Schools closed, garbage piled up on streets and many buses stopped running here in the capital on Monday because of a fuel shortage caused by a general strike called by ethnic minorities demanding more rights.
Assuming that this effect is not caused by a general reduced cell vitality induced by GO6976, and as detected by the MTT test performed in this study, a further cell adhesion mechanism seems to take place in this cell line.
This was partly caused by a general downward trend in grain prices and by the continuous subdivision of the habitant farms as each new generation inherited the land; habitant farms had been further sliced into ever narrower lots, each fronting a river or a road.
However, it cannot be excluded that the changed bile acid signature in MC was caused by a general response to the colonization and not induced by species-specific bile salt metabolism in the host.
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