Sentence examples for by causing a cellular from inspiring English sources

By causing a cellular redistribution of HKI, Aβ instigates an abnormal increase in mitochondrial ROS generation that is prevented by 2-deoxyglucose (2-DOG).

However, these NPs received recently considerable attention in order to manage their safe use and several studies concerning the characterization of NPs demonstrated potential cytotoxicity for many aquatic organisms by causing a cellular oxidative stress effect [ 1– 3].

By causing a substantial reduction in cellular PPAR-γ abundance, TGF-ß might be expected to attenuate the cell's ability to respond to PPAR-γ ligands.

Because both mitochondrial membranes are permeable to the hydrogen peroxide form of ROS [ 57- 59], the elevated ROS production by mitochondria accumulating in macromitophagy-deficient atg32Δ cells is likely to accelerate yeast aging by causing an excessive oxidative damage to extramitochondrial cellular macromolecules.

This action could be important for the treatment of cancer if cytosporone is used as an adjuvant because cyclophosphamide is cytotoxic to tumor cells by causing cellular injury such as DNA damage, including micronuclei, and by inducing a complex cascade of events that involve the activation of caspases and cysteine proteases [ 42].

This finding indicates that NHE1 activation may have directly triggered ERK1/2 phosphorylation, or indirectly by causing cellular injury which triggered oxidative stress and the release of vasoactive agents that induced ERK1/2 activation.

Cryoablation The application of extreme cold aims to destroy cells by causing both direct cellular and vascular injury [ 10, 11 ].

The efficiency of energy transfer between the donor and acceptor fluorescent proteins depends on the relative distance and orientation between them, which become altered by conformational changes of a fused sensory protein caused by a cellular event.

Currently, it seems clear the importance of the exposure to chemical mixtures and their contribution to the disease by causing cellular-level dysfunction along key pathways.

This side effect was caused by a cellular inflammatory reaction, attributed to a T helper cell type 1 response to epitopes located in the central and C-terminal part of Aβ(1 42) [12], [12].

Considering that hepatocytes represent 70 80% of the total liver cell mass [21], the estimated 40% cleavage of IPS1 observed in this patient could indicate that a relatively large fraction of hepatocytes were infected, unless IPS1 cleavage was caused by a cellular enzyme in uninfected cells in response to inflammation (see Discussion).