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A study of human cancer cells showed that increased p21WAF1/CIP1 levels, related to phosphatidylinositol 3-kinase (PI3K) pathway inhibition, induced chemoresistance by causing a cell cycle delay [ 43].
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Indeed, recently identified compelling evidence demonstrated that let-7 miRNAs target ERα and thereby repress estrogen signaling by causing a halt in cell proliferation and apoptosis [ 18].
The most commonly used anticancer chemotherapy and radiotherapy kill tumour cells by causing a wide variety of DNA damage.
Accordingly, depletion of Numb sensitizes cells to HGF-induced EMT by causing a decrease in cell cell adhesion and an increase in cell motility.
DDT works by causing an affected insects' nerve cells to fire repeatedly, leading to spasms and death.
He began one sentence, in an innocent tone, "I think we don't want to raise concerns that suvorexant causes narcolepsy by causing an autoimmune death of cells that produce orexins".
It is probable that Notch signalling can play a general role in tumour development in many different tissues by causing cells to adopt a proliferative cell fate.
However, overwhelming migration of activated neutrophils into the lungs can lead to a deleterious function by causing endothelial cell damage and unrestrained inflammation [ 8, 9].
DOI: http://dx.doi.org/10.7554/eLife.01236.001 Many cancer treatments work by causing cancer cells to enter an advanced stage of a process known as programmed cell death or apoptosis.
In this study, the sequential treatment with CDDP followed by GA caused a synergistic cell growth inhibition.
This value (0.11 µm/min), which closely approached the velocities observed in in vivo intravital imaging experiments16, indicates that TGF-β exerted a strong effect by causing cells to switch between a mode encompassing expansive growth with minimum movement to one defined by a strand migration state with high invasiveness.
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