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This presynaptic action produced by abused inhalants is shared by inhaled anesthetics and would contribute to the altered behavioral effects produced by both classes of drugs, and could be especially important in the context of a disruption of learning and memory by abused inhalants.
Of these, 17 were identified by both classes of baits.
The analyses presented here suggest that Ifnb1, Irf3, Irf5, Stat1, Stat2 and Nfkb2 all contribute to the control of genes regulated by both classes of interferon.
In view of the ability of COX-2/15-PGDH to rapidly metabolize AA to nM amounts of oxo-ETEs, together with the similar structural features of the oxo-ETEs and 15d-PGJ2, it will be important to determine which of these activities are shared by both classes of eicosanoids.
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By contrast, in both classes of Vpx the VR2 region contains a conserved di-tyrosine pair that interacts with the DCAF1 acidic loop to provide a hydrophobic platform for N- and C-terminal SAMHD1 degrons.
This could in theory be done pharmacologically by developing compounds that target both classes of proteins.
While multidrug resistance does not come as a complete surprise, researchers had hoped that HIV, by mutating to survive exposure to both classes of compounds, would have rendered itself incapable of infecting new hosts.
A related selective advantage is surmised for the prokaryotes coding for both classes of LysRS by the same organism.
If no assumptions at all are made about the form of the CPDFs, these functions must be estimated from the training set (correctly classified cases for both classes of patient) by certain nonparametric methods [ 18].
This resistance is believed to result from the quenching/repair of the O- 2-chloroethyl guanine and N, O- 2-chloroethyl guaninenk precursO- 2-chloroethyl guanineby both these clandes of ageNts.
The genome landscape of An. gambiae is represented by members of both classes, class I (retrotransposons) and class II (DNA transposons) [ 24, 27, 29], which constitute 6.85% and 5.9% respectively of the total An.
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