Sentence examples for by blocking the interaction from inspiring English sources
After screening roughly 40,000 compounds, they zeroed in on one that seemed likely to work by blocking the interaction between the virus and NPC1.
Assuming they utilize the same protein complex as vaccinia, he says, researchers may be able to fight these infections by blocking the interaction of the two proteins.
Antiviral microbicides, topical agents that prevent sexually transmitted infections, mainly work by blocking the interaction between viral proteins and cell surface components.
We tested C-82, a therapeutic that inhibits canonical Wnt signaling by blocking the interaction of the protein CBP with β-Catenin and inhibiting Wnt-activated genes.
ANG2 is produced by endothelial cells in hypoxic environments and would typically recruit pro-angiogenic cells, however binding of ANG2 with a monoclonal antibody inhibited angiogenesis by blocking the interaction of ANG2 with TIE2-expressing monocytes [44],[44].
Using the published RGS4-Giα1 X-ray structure, we have designed and synthesized a series of cyclic peptides, modeled on the Giα switch I region, that inhibit RGS4 GAP activity, presumably by blocking the interaction between RGS4 and Giα1.
Small aptamers that inhibit the virus at the stage of viral entry (e.g., by blocking the interactions between the viral envelope glycoprotein and the cellular receptor or co-receptor) have not been described so far.
Here, we identified a novel CD81 associated protein, EWI-2wint, which is able to inhibit HCV entry into target cells by blocking the interactions between HCV glycoproteins and CD81.
DNA methylation can silence genes by directly blocking the interaction of transcription factors to their regulatory sequences [ 7, 8].
Fucoidans demonstrated their antiviral activities by mainly blocking the interaction of viruses to the cells so as to inhibit viral-induced syncytium formation [ 74].
