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Squalene also exerted an antioxidant effect against isoproterenol-induced myocardial infarction by blocking the induction of lipid peroxidation.
Considering these differences in the pathogenesis of Salmonella and extracellular Gram-negative infections, one would envisage either beneficial effects of lipoproteins on the host resistance to Salmonella through blockade of cellular internalization, or deleterious effects by blocking the induction of cytokines by Salmonella LPS that are required for the activation of host defense.
This indicates that inhibition of WNT/β-catenin signaling has an anticatabolic effect by blocking the induction of MMPs by IL-1β and TNFα.
Related cytotoxins in E. coli and C. difficile act by glycosylating small GTP-binding proteins of Rho and Ras families, inhibiting the host signalling and regulatory functions [ 42], lymphocyte activation [ 43] and by blocking the induction of IFN-γ.
Interestingly, inhibitors of HDAC suppress COX-2 expression by blocking the induction of c-Jun and lead to the inhibition of viability and the induction of apoptosis (Yamaguchi et al., 2005).
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Calcipotriol might therefore decrease HBD2 expression in keratinocytes by two mechanisms: by directly blocking the induction of HBD2 through inhibition of Nf-κB and by lowering the tissue levels of IL-17A.
EGCG may exert at least part of its anticancer effect by inhibiting angiogenesis through blocking the induction of VEGF.
EGCG exerts, at least part of its anticancer effect, by inhibiting angiogenesis through blocking the induction of VEGF in both in vitro and in vivo studies, while EGC, ECG and EC have not demonstrated the same effect (Jung et al, 2001).
In vitro, MGP has been shown to inhibit calcification by binding to BMP2, thereby blocking the induction of osteoblasts [ 94].
These findings suggest that therapies targeting the cyclooxygenase pathway may diminish the propensity for tumour metastasis in HNSCC by blocking the PGE2-mediated induction of E-cadherin transcriptional repressors.
Overexpression of this protein inhibits the initial signal responsible for its own induction by blocking the Jak/STAT pathway.
More suggestions(15)
by blocking the lymph
by blocking the calming
by blocking the efflux
by blocking the cyclooxygenase
by blocking the broadcast
by blocking the proliferation
by blocking the surface
by blocking the flow
by blocking the integrin
by blocking the maintenance
by blocking the shot
by blocking the neddylation
by blocking the corticosterone
by blocking the intestine
by blocking the growth
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