Sentence examples for by blocking the classical from inspiring English sources
IL-10 inhibits TLR induced B-1P cell activation by blocking the classical NF-κB pathway.
High and rapid IL-10 production by B-1P cells upon TLR stimulation inhibited their own proliferation by blocking the classical NF-κB pathway.
Thus several observations support our hypothesis that blocking the classical nuclear transport pathway, including by induced nuclear accumulation of importin α under conditions of ATP depletion, results in the inhibition of apoptosis and promotion of non-apoptotic cell death.
Functionally, C4bp limits complement activation by blocking the formation of and promoting the decay of the classical pathway C3 convertase.
TNT003 specifically targets the classical complement pathway, potentially minimizing damage to the allograft by blocking the formation of the early products of HLA-Ab induced complement activation.
In the same experiment, we aimed to identify which complement pathway(s) are activated by M. leprae by pre-incubating NHS with either the anti-C1q neutralizing antibody to block the classical pathway or the C1 esterase-inhibitor (C1inh; Cetor), to block both the classical and the lectin pathways.
In monocytes, exogenous IL-10 inhibits TLR signaling by blocking classical NF-κB pathways via inhibition of IκB kinase (IKK) activity or p50/p65 translocation to nucleus, or by selectively inducing nuclear translocation of p50/p50 homodimer [39], [40], [41].
SCIN, a product of scn encoded on φSa3, inhibits complement activation via the classical, alternative and lectin pathways by blocking both the C4b2a and C3bBb C3-convertases.
Indeed, blocking Pgi eliminates the classical pathways for glucose consumption, but others are still available.
The foregoing discussion implies that blocking NF-κB activation by either the classical and/or the alternative pathway may be therapeutically beneficial for human RA inflammation.
Exceedance probabilities of practically important duration levels are estimated by the classical block maxima model for extremes and the point process model.
