Sentence examples for by blocking the association from inspiring English sources

Such CAR-RIAD T cells showed enhanced antitumor activity in vitro and showed more efficient migration to tumor sites in vivo by blocking the association of PKA with ezrin to blunt the inhibition of PKA on TCR activation.

Thus, C/EBPalpha inhibited cdk2 activity by blocking the association of cdk2 with cyclins to bring about growth arrest.

Our lead compound significantly inhibited ERα transcriptional activity by blocking the association of coactivators at the AF2 site.

Suramin disrupts GPCR binding with the G protein by blocking the association of G protein α and βγ subunits [ 28].

Previously, it has been shown that it is possible to inhibit ERα transcriptional activity by blocking the association of coactivators at the AF2 site.

Pertuzumab (Omnitarg™) is a fully humanised monoclonal antibody, which acts by blocking the association of HER2 with other HER family members, including the epidermal growth factor receptor, HER3 and HER4 (Adams et al, 2006).

In agreement with this hypothesis, blocking of actin dynamics by cytochalasin B treatment or blocking the association of Cx43 with the actin cytoskeleton led to a significant increase in the gap junction size [ 39, 40].

As we have argued, if the association between time on CV and mortality arises through damage to the lungs caused by CV, we expect that conditioning for OI as a marker of lung injury would explain this association by blocking the effect; that is, by adjusting for OI as an intermediate cause, the association of time on CV with mortality would disappear.

These Scd6p-containing complexes could possibly either target bound mRNAs for degradation or, conversely, stabilize the mRNAs by blocking their association with the Lsm1-7p complex involved in decapping.

Another mode of inhibition of HDM2 is by blocking its association with the proteasome.

Mdm2 also inhibits p53 transactivation by blocking p53 association with the transcription machinery [ 25- 28].