Sentence examples for by blocking the activation from inspiring English sources

In support to the present findings, proteasome inhibitors have been demonstrated to have anti-inflammatory activities by blocking the activation of NF-kappaB and by reducing the production of inflammatory mediators and cytokines [ 47, 48].

CHS-111 was subsequently found to reduce levels of active GTP-bound RhoA by blocking the activation of the RhoA-specific GEF Vav.

VA RNAI acts against cellular antiviral defense by blocking the activation of the protein kinase PKR, which when activated turns off protein synthesis in infected cells [ 56].

Recently, it has been observed (Murakami et al, 2007) that PEITC suppresses receptor activator of NF- κB ligand-induced osteoclastogenesis by blocking the activation of ERK1/2 and p38 MAPK in RAW264.7 macrophages.

The anti-inflammatory effects are achieved by blocking the activation of NF-κB, secreting anti-inflammatory cytokines, and inhibiting the release of pro-inflammatory cytokines, such as TNF-α and IL-6 (Tilg and Moschen, 2006).

The process is further enhanced by elevating the production of the chemoattractant SDf-1α and may also be boosted by blocking the activation of microglia.

Like the regulation on AKT, the network reveals that NF-κB can be influenced by multiple pathways induced by EGCG: blocking the activation of NF-κB by quenching ROS [ 40], inhibiting the upstream regulators such as PI3K/Akt and MAP kinases [ 12], or inhibiting Pin1, a NF-κB chaperon protein [ 41].

X-linked inhibitor of apoptosis is a member of intracellular antiapoptotic proteins that confers protection form death-inducing stimuli by directly blocking the activation of caspases (Deveraux et al, 1999).

Endocrine-disrupting compounds are commonly considered as molecules acting either by mimicking or by blocking the transcriptionnal activation of hormone nuclear receptors such as those for estrogens, androgens, progestagens, thyroid hormones etc [1], [2].

This will assist in explaining the roles of TH on the maintenance of viral latency, probably by blocking the α activation in latently-infected mice upon reactivation.

Angiotensin II type 1 (AT-1) receptor blockers reduce renin-angiotensin system activity by blocking the receptor, the activation of which is responsible for the majority of deleterious angiotensin II effects.