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They work by blocking production of angiotensin, a blood vessel constricting protein.
Ibuprofen and similar drugs may raise blood pressure by blocking production of prostaglandins, hormone-like substances that can widen blood vessels and improve blood flow.
Dr. Jean-Louis Guenet of Pasteur, a co-author of the study appearing this week in The Proceedings of the National Academy of Sciences, said the West Nile gene allows the virus to cause disease by blocking production of a group of proteins that normally prevent viruses from reproducing inside a cell.
Aspirin and its cousins work by blocking production of cyclooxygenase (COX) enzymes.
IPNV infection can up-regulate pro-apoptotic genes during the early-middle replication stage, as seen in Figure S2, and this up-regulation can be suppressed by blocking production of TNFα (Figure 3).
Using synthetic biology, Gevo has engineered a yeast to concentrate on production of isobutanol by blocking production of ethanol and acetic acid [ 16].
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Other media additions increased ethanol production by thermodynamically blocking production of another competing metabolic byproduct, such as acetate, as is seen experimentally in a metabolic shift assay.
Specifically, Muchamuel and colleagues [ 27] showed that selective inhibition of the immunoproteasome by ONX 0914 (PR-957) blocked production of IFN-γ and IL-2 by T cells in mouse models of arthritis, thereby reversing disease symptoms along with reducing cellular infiltration in arthritic lesions and autoantibody levels.
Meanwhile, some studies revealed that RNA polymerase III was involved in detection of cytosolic DNA and triggering production of type I in human cell, and inhibition of RNA polymerase III also blocked production of interferon induced by DNA virus, such as Herpes simplex virus-1 (HSV-1) and Epstein-Barr virus (EBV) [ 38– 40].
Prednisolone reduces inflammation by blocking the production of chemical mediators of inflammation.
We investigated the influence of CO by blocking endogenous production of this gasotransmitter via HO using ZnPPR IX.
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by blocking reform of
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