Sentence examples for by blocking interaction of from inspiring English sources

The appropriate chemokines have been shown to inhibit viral replication by blocking interaction of the gp120 envelope protein with the coreceptors.

It recognizes both soluble and membrane-bound TNF-α with high specificity and high affinity (Kd = 6 × 10-10 M) and inhibits its biological activity by blocking interaction of TNF-α with p55 and p75 receptors [ 37].

They bind Rho GTPases and prevent their activation by means of blocking interaction of the GTP-bound form with effectors, sequestering GDP-bound Rho proteins in the cytoplasm away from the GDP-GTP cycle, as well as by changing membrane compartment to GTPases [ 12].

Montelukast, a leukotriene receptor antagonist, inhibits the cytokine production of ILC2s by blocking interaction between leukotriene D4 and cysteinyl leukotriene receptor 1 (CysLT1R) expressed by ILC2s (Doherty et al., 2013).

The peptide, which inhibits JAM-A/leukocyte interaction by blocking the interaction of the C2 domain of JAM-A with LFA on neutrophils and monocytes/macrophages, attenuated I/R-induced neutrophil and monocyte infiltration into brain parenchyma.

By blocking the interaction of CD11a and of the intercellular adhesion molecule-1 (ICAM-1), efalizumab interferes at multiple levels with the pathogenesis of psoriasis, inhibiting leukocyte trafficking into the skin as well as the continuous activation of T-lymphocytes by antigen-presenting cells in the dermis and epidermis.

Abatacept is thought to inhibit stimulation of T cells by blocking the interaction of CD80/CD86 B7-1/B7-2 B7-1/B7-2 B7-1/B7-2

Alternatively, CS could be acting outside of the cell by blocking the interaction of MSU or extracellular matrix fragments with cell surface receptors on macrophages [ 28].

The beneficial effect of lipoproteins was exerted by blocking the interaction of Salmonella with host cells, including endothelial cells and monocytes, which led to inhibition of organ invasion.

CNE inhibits C2C12-mediated PDGF-BB-stimulated contraction of pure collagen gels, presumably by blocking the interaction of cell-produced fibronectin with the native collagen fibres [ 36].

Rapamycin-FKBP12 has been proposed to inhibit mTOR function by blocking the interaction of raptor with mTOR and thereby disrupting the coupling of mTORC1 with its substrates [27].