Sentence examples for by blocking heterodimerization of from inspiring English sources
To further determine whether osajin inhibits the function of Bcl-2 by blocking heterodimerization of Bcl-2 and Bax, co-immunoprecipitation with Bcl-2 and Bax was performed.
We assessed whether apoptosis could be induced in prostate tumour cells by blocking this heterodimerization with synthetic peptide sequences derived from the BH3 domain of pro-apoptotic Bcl-2 family members.
Pertuzumab, the second commercially approved selective anti-HER2 agent, may act in synergy with trastuzumab to antagonize HER2 signaling by blocking HER2 heterodimerization and activating antibody-dependent cell-mediated cytotoxicity [ 15].
Pertuzumab is a HER2-specific humanized monoclonal antibody, which inhibits ligand-mediated intracellular signaling by blocking functional HER2 heterodimerization (Agus et al, 2002; Mendoza et al, 2002).
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AP1 also appears to be involved in negative regulation of HPV transcription, since treatment of HPV16 immortalized human keratinocytes with the anti-oxidant pyrrolidine-dithio-carbamate (PDTC) selectively reduced the amount of viral mRNA by blocking transcription initiation, an effect that is profoundly associated with alterations of the AP1 heterodimerization pattern [ 20].
Although the molecular mechanism by which A5 induces its therapeutic effect is not fully elucidated here, one potential mechanism is through blocking ligand-induced heterodimerization of ErbB3.
The pharmacologically active GABAB receptors are formed by heterodimerization of GABAB1 and GABAB2 subunit proteins encoded by GABBR1 and GABBR2 genes, respectively.
Interleukin-2 (IL-2) regulates lymphocyte function by signaling through heterodimerization of the IL-2Rβ and γc receptor subunits.
Rapamycin is a safe and widely available immunosuppressive pharmaceutical that acts by heterodimerization of FKBP12 with the FRB fragment of mTOR.
In contrast, antagonism between vitamin D and vitamin A, mediated by heterodimerization of ligand bound vitamin D receptors with RXR, also has been reported [76].
