Sentence examples for by blocking expression of from inspiring English sources

Bmi-1 prevents stem cell aging, at least partly, by blocking expression of the cyclin-dependent kinase inhibitor p16Ink4a.

The A β toxicity can be prevented by blocking expression of Kv channel interacting protein 3 [ 23].

Indeed, miR-221 mediates PDGF-induced phenotypic changes in VSMCs by blocking expression of SMC contractile genes and stimulating VSMC dedifferentiation, proliferation, and migration.

It has been reported that miR-21 contributes to the malignant phenotype of tumor cells by blocking expression of critical apoptosis-related genes in human cancer cell lines.

Our findings define a novel positive regulatory feedback loop through which TGFβ signaling further induces its effects by blocking expression of the Smad inhibitor BCAR3.

In this screen, we identified abrupt (ab), which in cooperation with scrib loss-of-function promotes the retention of a progenitor-like cell state by blocking expression of differentiation genes, as well as promoting tumour growth and invasion.

AHR-1 specifies AVM touch neuron fate by elevating MEC-3 while simultaneously blocking expression of nociceptive genes such as the MEC-3 target, the claudin-like membrane protein HPO-30, that promotes the complex dendritic branching pattern of PVD.

In glioblastoma cells, for example, by blocking the expression of HIF1 α and hence the expression of various enzymes of the glycolysis cycle, FTS causes a severe energy deficit, leading eventually to cell death.

IL-10 appears to limit and ultimately terminate inflammatory responses by blocking the expression of a number of pro-inflammatory cytokines and chemokines [ 15].

Taken together, these results suggested a mechanism underlying the beneficial effect of cimetidine on colorectal cancer patients, presumably by blocking the expression of E-selectin on vascular endothelial cells and inhibiting the adhesion of cancer cells.

Previously, we reported that PL, at high doses, induces control lung epithelial cells to arrest in the G1 phase of the cell cycle by blocking the expression of cyclin D1 and its interaction with cell cycle-dependent kinases 4 and 6 [6].