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In ischemic conditions, CDP-choline (cytidine-5′-diphosphate choline; citicoline) is thought to act by blocking cell membrane degradation and release of toxic arachidonic acid and perhaps other harmful components of this process.
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Inhibition of GSK-3β activity using well-characterized inhibitors, LiCl and kenpaullone, and RNA interference, prevented MPP+-induced cell death by blocking mitochondrial membrane potential changes and subsequent caspase-9 and -3 activation.
In a highly cellular tissue, extracellular water would not be able to diffuse far during the MR observation period without being blocked by cell membranes; this would lead to a short diffusional path and a reduced ADC (Fig. 3).
(R -roscovitine is a membR -roscovitine cyclis-dependent kinase inhibitor, designed to block cell division.
Studies have shown that the activation of GluR causes a large influx of Na+ and Ca2+ ions through the cell membrane by blocking K+ currents in NG2 cells, thereby leading to the depolarization and inhibition of cell proliferation [ 67, 68].
It blocks off cell membrane ion transporters that are responsible for keeping cell function in check.
The broad-spectrum antiviral arbidol (Arb) inhibits cell entry of enveloped viruses by blocking viral fusion with host cell membrane.
Late stages of fusion were affected by PtdIns(4,5) P2-targeting reagents and by modifying the functional activity of dynamin either by expressing different dynamin mutants or by blocking dynamin GTPase activity with cell-membrane-permeant inhibitors.
Lipids are the building blocks of cell membranes, and their turnover is regulated by specific enzymes, including lipases and acyltransferases.
Fatty acids are major building blocks of cell membranes, which are products of cellular biosynthesis.
In common with other local anaesthetic agents, it is widely accepted that levobupivacaine blocks nerve conduction in sensory and motor nerves by blocking voltage sensitive sodium channels in the cell membrane.
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