Sentence examples for by blocking cell division from inspiring English sources
This paper shows that NBPF1 can exert its tumor suppressive effect in different ways: by blocking cell division, inducing cell death, or by modulating a cancer-associated proteome.
The fact that tested natural extracts act by blocking cell division after primary inhibition of DNA synthesis is reminiscent of the chemotherapeutic agents included in the quinolone family [ 25].
By blocking cell division from the gastrula stage, we show that cell proliferation is not essential for differentiation of cardiomyocytes, and the resulting heart remains essentially normal in size, as determined by the expression of markers of cardiac differentiation.
Nowadays most of drugs used in chemotherapy express their activity by blocking cells division or inducing apoptosis in dividing cells.
Taken together these findings demonstrate that directly blocking the cell division through CDC25 loss is less damaging to the intestinal mucosa than is blocking cell division by inducing DNA damage with chemotherapy.
We report that the phenotypes arising in mice globally deleted for the Cdc25s are due to the failure of small intestinal stem and progenitor cells to proliferate and that blocking cell division by inhibiting the cell cycle engine (through Cdc25 loss) versus by inducing DNA damage (via irinotecan) provokes a markedly different response of small intestinal epithelial cells.
Sirolimus, a macrocyclic lactone, inhibits mammalian target of rapamycin (mTOR) thereby blocking cell division by interfering at the transition from G1 to S phase.
The most important contribution of this and previous work is that p53 can no longer be regarded as a bona fide "senescence inducer" and that its role is mainly to block cell division (by stimulating p21), thus permitting the onset of senescence program under appropriate conditions [ 7].
(R -roscovitine is a membR -roscovitine cyclis-dependent kinase inhibitor, designed to block cell division.
This implicated that other mechanisms blocked cell division.
