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The results showed that these compounds exhibited good and selective inhibitory activities against MV4-11 cells with the IC50 values of 11.67 μM, 5.55 μM, and 11.54 μM, respectively, and could act on the cell proliferation by blocking cell cycle at G1 phase.
In addition, TRAIL blockade results in hyperproliferation of synovial cells and lymphocytes, whereas TRAIL inhibits DNA synthesis in lymphocytes by blocking cell cycle progression [7].
These toxins, termed cyclomodulins, can promote cell proliferation or, conversely, inhibit cell growth and modulate differentiation by blocking cell cycle progression [1], [2].
PLK2 inhibits apoptosis by blocking cell cycle progression, thus maintaining genomic integrity.
We observed that estrogen increased proliferation potentially by blocking cell cycle checkpoints.
The suppression of cell proliferation could be promoted by blocking cell cycle entry.
Similar(46)
Some viral co-infections can modulate HIV-1 entry in vitro, mainly by modulating chemokines and chemokine receptors [43] [45]; and measles virus has been able to interfere with HIV-1 reverse transcription and replication by blocking cell-cycle progression of CD4+ T lymphocytes [46].
In conclusion, calycosin can inhibit cell growth of BEL-7402 blockinging cell-cycle and regulating some tumor genes translation.
Thus Oct-4 down-regulation in ES cells inhibits cellular proliferation by blocking cell-cycle progression in G0/G1.
We found that down-regulation of oct-4 expression led to the growth arrest of ES cells by blocking cell-cycle progression in G0/G1.
Collectively, these results illustrate that the miR-16 family could efficiently repress the proliferation and viability of HepG2-hbx cells by blocking cell-cycle progression and inducing apoptosis.
More suggestions(15)
by blocking cell division
by analyzing cell cycle
by blocking cell migration
by blocking cell wall
by blocking cell differentiation
by processing cell cycle
by promoting cell cycle
by modulating cell cycle
by blocking cell membrane
by coordinating cell cycle
by blocking cell death
by blocking cell survival
by blocking cell growth
by blocking cell binding
by blocking cell adhesion
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