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Immune sera inhibit MHV-68 infection of fibroblasts [24], probably by blocking cell binding [25].
Immune sera appear to block MHV-68 infection of fibroblasts [25], [26] primarily by blocking cell binding [27].
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Merely blocking cell binding may therefore not suffice to block viral transmission.
The most advanced demonstrations of structure-based multivalent ligand designed to date are the development of pentavalent and decavalent carbohydrate inhibitors that are capable of blocking cell surface binding by AB5 toxins.
Nor did a gB-NT-specific neutralizing mAb block cell binding by gB-Fc, consistent with the idea that these mAbs do not act by blocking binding (Gillet et al, 2006).
IAPs function to block cell death by binding to and inhibiting the action of caspases involved in the execution phase of apoptosis (Holcik and Korneluk, 2001; Holcik et al, 2001).
Interestingly, treatment with Pluronic F-127, which inhibts cell-adhesion by blocking hydrophilic binding sites of common cell culture substrates like polystyrene or polyethylene, reduced the number of fibroblasts on the bottom of the cell culture plates while the silk seeding remained unaffected (data not shown).
Thus, ipilimumab sustains the proliferation and antitumour effect of T cells by blocking the binding of CD80 and CD86 to CTLA-4.
Finally, we tested whether the purified IgG could also block endothelial cell binding by parasite-infected erythrocytes expressing IT4var20, a PfEMP1 shown to bind only to EPCR (Turner et al., 2013).
The action of cholera toxin and E. coli heat-labile enterotoxin can be inhibited by blocking their binding to the cell-surface receptor GM1.
Salicylate inhibits COX-2 transcriptional activation in quiescent cells but not in serum-driven proliferating cells by blocking C/EBPβ DNA binding.
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