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The set of individual differentially expressed genes can only tell us which genes are altered by biological differences between different cell types and/or states.
To correct for the potential deviations between the real and measured DNA quantity caused by biological differences between species, we propose the use of calibration curves generated from each analyzed matrix.
It is unclear whether these differences are caused by biological differences between tissues, genotypes, or differences in the expression profiling platforms.
Different cell types, such as neurons, glial cells and follicular dendritic cells (36), can exhibit different cytopathological changes when infected with the same strain of TSE agent; this is most likely caused by biological differences between these cell types.
It does, however, suggest that only a small proportion of the survival advantage of screen-detected cancers remains to be explained by biological differences between screen-detected and symptomatic tumours.
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The gap in cancer survival cannot be explained away by biological differences in cancer between blacks and whites, researchers say.
The differences introduced by RNA degradation were largely outweighed by the biological differences between the patients.
Although this result might have been caused by the biological differences between pGBM and adult cancers or by the pGBM CSC properties, our intriguing finding may also reflect the complex nature of gene expression regulations in human cancers.
Part of it may be explained by the biological differences between men and women.
Furthermore, conflicting results about the predictive role of EGFR gene copy number could be explained by possible biological differences between early (first line or maintenance) vs late (second and third line) settings.
Other experiments at our facility using the more recent Illumina Human HT-12 and Mouse Ref 8 BeadChips exhibit similar batch effects to those in this study; samples are observed to cluster preferentially with others processed in the same run, rather than by the biological differences between them, even after quantile normalisation (data not shown).
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