Sentence examples for by binding with high from inspiring English sources

It acts primarily by binding with high affinity to the IGF-I tyrosine kinase receptor (IGF1R) and its activity is modulated by IGF-binding proteins (IGFBP) [3].

This complex then augments or represses estradiol-specific gene expression by binding with high affinity to sequence-specific cis regulatory motifs contained within the promoters of target genes (reviewed in [10]).

Certain human GST isoforms have been shown to exert their protective effects through this ligandin-like behavior by binding with high affinity to inhibitory prostaglandins (e.g., PGJ2), effectively sequestering them in the cytosol away from target nuclear proteins and preventing effects on gene regulation [39], [43].

Zinc finger proteins are cellular proteins which play a major role in transcriptional regulation by binding with high affinity to specific regions of DNA.

Later in life, these previously quiescent QKRAA-specific T cells can be activated by binding with high avidity an exogenous peptide containing the SE [ 101].

It inhibits mTOR by binding with high affinity to its internal receptor, FKBP12 [FK506-binding protein 12 (FK506 is an immunosuppressant macrolide)].

A ligand can shift a protein's folding/unfolding equilibrium by binding with higher affinity to the native state.

In contrast, Invasin, which was first described by Isberg and coworkers, enhances the ability of Yersinia spp. to enter target cells, not by binding to a Tir-like protein, but by binding with high-affinity to multiple members of the β1-chain integrin family of mammalian cell receptors.

The objective of this study was to develop tools for characterizing substances that mediate estrogenic activity in complex mixtures, that is, to determine if the estrogenic compounds were ER activators by direct binding (with high or low affinity) or ER activators by another mechanism of action (AhR activation).

Voltage-independent inhibition by Zn2+ binding with high affinity within the ATD is highly subunit selective (GluN2A >> GluN2B > GluN2C ≥ GluN2D; 197, 197).

Furthermore the loss of EphB2 function was triggered by Aß oligomer binding with high affinity to this receptor, which was subsequently internalized.