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MicroRNAs (miRNAs) are small regulatory RNA that mediate RNA interference by binding to various mRNA target regions.
In most cases, lncRNAs exert their function by binding to various RBPs, such as WDR5, GADD45A and hnRNPK.
Non-complexed HNTMB displayed partial cytotoxicity and by binding to various trace metals is likely to disturb a multitude of functions important for cell proliferation and survival.
In addition, recent in vitro studies have shown that rhAPC can modulate the endothelium by binding to various receptors that are important for endothelial cell integrity [ 9].
The Neh3 5 domains are thought to function in transactivation by binding to various components of the transcriptional apparatus [29], [30].
Proximal upstream regions of a gene in particular contain many cis-regulatory elements that regulate the expression of the gene by binding to various transcription factors.
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These components do not seem to have direct structural roles but modulate cell functions such as collagen fibrillogenesis, cell adhesion, migration, proliferation, and differentiation by their binding to various molecules; such as cell-surface receptors, growth factors, cytokines, proteases, and type I collagen [1].
However, most genes are controlled cooperatively by several transcription factors (TFs) binding to various regulatory elements [ 6- 8].
Previously, we assessed SBD binding to various lipids by lipid-protein overlay (fat-blot) assay, and found no detectable interaction with glycosylated and non-glycosylated sphingoid bases, sphingosylphosphocholine, ceramide, sulfatide, cholesterol, glycerophospholipid, and myriocin [51].
By binding to adrenoceptors in various organs, NE and EPI may modulate various intracellular molecular pathways already implicated in cancer (see below).
These molecules exert cytotoxic effects by binding to DNA through various mechanisms.
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