Sentence examples for by binding to unique from inspiring English sources
The amino-terminus of CIN85 contains three SH3 domains known to mediate protein protein interactions by binding to unique proline-rich motifs.
CDP acts as a transcriptional repressor by binding to unique nucleotide sequence elements and is also involved in the regulation of gene transcription through nuclear matrix attachment (22).
Moreover, it was shown that CREBH directly regulated human APOA5 gene expression by binding to a unique CREBHRE located in the proximal human APOA5 promoter region, using 5′-deletion and mutagenesis of human APOA5 promoter analysis and chromatin immunoprecipitation assay.
With breast cancer progression, we have detected an increase in the percentage of samples positives for RXRs isoform; since RXR are needed partners of different nuclear receptors and there is an alternative pathway of activation for RXR as a homodimer by binding to a unique response element [ 31], this increase could be related to the several modifications that occur in the malignant progression.
LEV seems to act by a unique mechanism; modulation of synaptic release of neurotransmitters by binding to the synaptic vesicle protein 2A (SV2A) [ 16, 17].
But the good news was that it had a unique mechanism of action — it interfered with cell division by binding to what is called the spindle protein — and its side effects were different from those of the other drugs.
Pegvisomant is unique in that it does not inhibit GH secretion, but rather inhibits GH action by binding to and blocking the GHR (Kopchick et al., 2002).
Specifically, it inhibits recognition of acetylated lysines relevant to actively transcribed chromatin by binding to the bromodomain-binding pocket.
The paradigm for eukaryotic activator-dependent transcription relies on such recruitment: DNA-binding transcription factors provide specificity by binding preferentially to unique sequences, and then recruit a number of coactivators, such as complexes involved in chromatin remodeling and adaptors between activators and polymerase, as well as the actual transcription machinery itself.
