Sentence examples for by binding to type from inspiring English sources

While the BMP subfamily signals by binding initially to transmembrane serine threonine kinase type I (BMP) receptors, the TGF-β and activin A family ligands signal by binding to type II receptors, but do not bind directly to type I receptors [ 20].

Dual specific A-kinase anchoring protein 2 (D-AKAP2) is a scaffold protein that coordinates cAMP-mediated signaling complexes by binding to type I and type II protein kinase A (PKA).

In the canonical TGFβ signaling pathway, active TGFβ ligands initiate signaling by binding to type I and type II receptor serine/threonine kinases.

Extracellular ATP has been reported to trigger the release of IL-1β by binding to type 2 purinergic receptors (P2 receptors) [8].

BMPs mediate their effects by binding to type I and II serine/threonine kinase receptors, leading to the activation of the intracellular Smad pathway.

Smad7 is an inhibitory protein that interferes with the phosphorylation of pathway-restricted SMAD proteins such as Smad2 and SMAD3 by binding to type I receptors [ 11, 32].

The generated antibodies were confirmed for their specificity by binding to type-specific HDAgs expressed in DNA-transfected Huh-7 hepatoma cells.

Follistatin binds to activin to neutralize its activity by prevent its binding to type II receptor, therefore blocking myostatin activity when transgenic expression of follistatin specifically to skeletal muscle [ 5].

Signal transduction of TGF-β proteins is initiated by binding to two types of receptors named type I and type II [1], [5].

TGFβ ligands initiate the signalling by binding to a type II receptor on the cell surface that in turn binds and phosphorylates a type I receptor.

Doi et al. [ 43] reported that secreted Klotho suppresses TGF-β1 signaling by directly binding to type-II TGF-β receptor (TGFβR2) on the cell surface and preventing TGF-β1 binding to that receptor.