Sentence examples for by binding to several from inspiring English sources
Activation of anti-apoptotic genes by Shh signaling is the simplest scenario, and indeed, Gli1 can activate BCL2 gene expression in human cell lines and in the mouse keratinocytes by binding to several near-consensus sites in the BCL2 promoter [14].
By binding to several G-protein-coupled receptors it acts as pleiotropic mediator of multiple cellular effects [ 24].
Ox-LDL acts by binding to several SRs, including SR-A, SR-BI, CD36, and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and transforms macrophages to foam cells, which are a hallmark of atherosclerosis.
The antagonistic effect of Wif-1 is exerted by binding to several Wnt ligands, both canonical and non-canonical, thereby interfering with their induction of Wnt signaling although not all of the regulatory mechanisms of Wif-1 are understood.
p63 directly regulates Fgfr2 and Fgfr3 transcription by binding to several regulatory regions in the Fgfr2 and the Fgfr3 loci, and Fgfr2 primary transcripts are affected in p63 +/L514F keratinocytes, suggesting that an important level of dysregulation in AEC syndrome occurs at the transcriptional level.
14-3-3 14-3-3 14-3-3 14-3-3nal phospho-serine/phospho-threonine binding protein, is emerging as an effector of pro-survival signaling by binding to several proteins involved in apoptosis (Bad, FKHRL1 and ASK1) and may serve as an appropriate target for head and neck cancer therapy.
Long-range effects of a TF can be achieved by cooperative binding to several binding sites or by DNA looping.
In summary, NFAT1 induces GPC6 expression by direct binding to several elements on the GPC6 proximal promoter.
Neurexins mediate synapse formation by trans-synaptic binding to several postsynaptic partners including neuroligins, LRRTMs and GluRδ2 [9]–[15].
Telomeric heterochromatin is modulated by TERRA through binding to several telomeric proteins: telomere repeat factors (TRF1, TRF2), origin recognition complex (ORC), HP1, and H3K9me3.
IAPs, including survivin and XIAP, function by binding to and inhibiting several caspases, such as caspase-9 [ 33].
