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Many drugs work not by combining with specific receptors but by binding to other proteins, particularly enzymes and transport proteins.
Moreover, increasing the injected mass of radioligand can diminish the pharmacological selectivity by binding to other SSTR-positive organs [22], which is not beneficial in the case of TAT and may cause off-target toxicities.
In contrast, MUC16 has also been demonstrated to mediate cell adhesion by binding to other cell surface glycoproteins such as galectin-1 and mesothelin [14], [15].
The data reported in this study indicates that Foxp3 achieves nuclear transport by binding to other nuclear factors and co-transporting with them to the nucleus.
Proteins perform their biological functions by binding to other molecules.
By binding to other molecules, NGAL may exceed size limits for passage through the filter.
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Likewise, similar effects are expected to be caused by ligand binding to other filamin domain pairs.
By then binding to other ligands at "the front of the movement," the neutrophil is able to move on.
The recognition of substrates such as Z-VAD in dying cells might be explained by the binding to other proteases acting in the Leishmania CD pathway.
Essential for keeping the protein in this conformation is a short stretch of highly conserved amino acids that inhibits the transcriptional activity of TAp63 α by directly binding to other p63 domains.
ER and its coregulators are phosphorylated and activated by PI3K signaling, here through PTEN KD, which may convert ER from a classical ERE-mediated transcription factor to a non-classical transcription factor mediated by its binding to other sites on DNA [ 40, 41].
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