Sentence examples for by binding to multiple from inspiring English sources
Decorin, a leucine-rich proteoglycan that is produced by decidual cells, limits invasion and endovascular differentiation of extravillous trophoblast cells during early placentation by binding to multiple tyrosine kinase receptors, in particular, vascular endothelial growth factor receptor-2.
It seems to work by binding to multiple targets, she said, which may slow down the development of resistance.
For example, c-MYC occupation is associated with genome-scale alteration of chromatin structure and histone accessibility [13], [93], possibly by stimulation of DNA replication [94] or by binding to multiple sites [24]; while KLF4 regulates histone acetylation [24], [95].
Many proteins function by binding to multiple partners.
Many receptors function by binding to multiple ligands, each eliciting a distinct biological output.
Proteins that are involved in these processes act as 'universal adapters' by binding to multiple ligands and connecting otherwise disconnected ligands to each other.
NF-κB activates the expression of cyclin D1, a positive regulator of G1-to-S-phase progression, by direct binding to multiple sites in its promoter [ 35].
In this step, negatively charged cofactors are thought to induce conformational changes in the intrinsically disordered Tau monomers and to increase the local Tau concentration by simultaneously binding to multiple positively charged monomers.
Stat3 has been previously implicated in the regulation of genes involved in cell survival and proliferation by directly binding to multiple survival genes, including Bcl2, Fos, Jun, Mcl1 and Fosl2 (Hirano et al., 2000; Bourillot et al., 2009; Durant et al., 2010; Carpenter and Lo, 2014).
In animals, they target mRNAs by recognizing and directly binding to multiple partially complementary sites preferentially located in the 3' untranslated regions (UTRs) of transcripts.
By spreading a target binding to multiple sites along the ANK repeats inner groove that are not directly coupled, each binding site can be regulated independently and in a graded fashion.
