The antibody detected INH binding to many hepatic proteins, and the binding was specific, i.e., no binding was observed to hepatic proteins from untreated controls, and binding was blocked by preincubation of the serum with INH.
HIV enters white blood cells by binding to CCR5, and many HIV drugs work by interfering with this binding.
miRNAs (20 22 nt long) are know factors that suppress expression of many genes by binding to target sequences in the 3'UTR of many mRNAs.
HIF1α has been reported to regulate Vegf gene expression by binding to the promoter region in many types of cells28,29.
Zeb2, a master regulator of the mesenchymal state, exerts its effect by binding to E-box elements upstream of many genes, including E-cadherin, and repressing their transcription.
NFATc regulates the expression of many genes by binding to DNA as dimers or in cooperation with other transcription factors.
We presume that Cd also enters the mitochondria and inhibits the activities of many enzymes by binding to their −SH groups or by inhibiting the protein synthesis [ 37].
Tristetraprolin (TTP), an mRNA-binding zinc-finger protein, destabilizes many mRNAs by binding to AU-rich elements (AREs) in their 3' untranslated region [ 11], and subsequently targeting them to exosomes or proteasomes [ 12, 13].
Thus, activated IRF1 regulates the promoter function of IFNα/β promoter and acts as a modulator of many ISGs by binding to the ISRE in the promoter region, thereby regulating viral replication (Table 1).
ZFP36 destabilizes the mRNA of many proinflammatory genes by binding to an AU-rich element (ARE) located at the 3' untranslated region (UTR) of their mRNA [11], [12].
