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Carbon monoxide produces its lethal effects by binding to hemoglobin and preventing oxygen transport.
As an environment rich in reduced GSH, RBC would naturally convert garlic's organic polysulfides to H2S, which presumably can circulate to the whole body by binding to hemoglobin and other hemoproteins [5], [43].
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CO mediates its toxic effects primarily by strongly binding to hemoglobin and forming carboxyhemoglobin (COHb), thereby reducing the oxygen-carrying capacity of the blood.
The origin of such changes in dynamics is unclear, but some clues are provided by the simulations of diphosphoglycerate binding to hemoglobin (37).
Like fibrinogen, haptoglobin is an acute phase protein that inhibits hemoglobin-induced oxidative tissue damage by binding to free hemoglobin (110).
The dose response of adduct binding to hemoglobin and DNA appeared to be similar.
Preferential accumulation of arsenic in rat blood was attributed to arsenic binding to hemoglobin.
Specifically, we found that upon binding to hemoglobin, 5-hydroxyprimaquine is able to donate an electron to the hemoglobin-bound O2.
Upon binding to hemoglobin, the Hp 1 protein is superior to the Hp 2 protein in protecting against oxidation mediated by Hb derived iron [ 20] and HDL dysfunction, [ 21] particularly in the setting of diabetes.
Free hemoglobin is eliminated by binding to plasma protein haptoglobin and then transported into cells of monocytic lineage via receptor CD163 [ 6].
Neuroglobin (Ngb) is a protein which regulates neuronal oxygen homeostasis by binding to oxygen with a higher affinity than hemoglobin [ 62].
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