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DNA strand breaks induce PARP-1 activity, which triggers DNA repair by binding to damaged DNA.
Fibrin sealants formulated as a self-expanding foam (fibrin-fix-a-flat) have been designed to fill a cavity and reduce blood loss by binding to damaged surfaces.
The XPA protein is noncatalytic but plays an important role in NER by binding to damaged DNA, recruiting several players to the site and positioning them for action (reviewed in [ 7]).
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This result supports the hypothesis that the MSH2-dependent pathway is initiated by specific protein conformational changes triggered by binding to either DNA damage or small compound molecules.
Antibodies contribute to immunity in three ways: They prevent pathogens from entering or damaging cells by binding to them; they stimulate removal of pathogens by macrophages and other cells by coating the pathogen; and they trigger destruction of pathogens by stimulating other immune responses such as the complement pathway.
The question is, why?PCBs do their damage by binding to a protein called the aryl hydrocarbon receptor, or AHR, thus stopping it working properly.
Secondary antioxidants suppress the formation of radicals and protect against oxidative damage by binding to metal ions strongly.
Most of the platinum complexes cause DNA damages by binding to the DNA, which leads to DNA conformational changes to stop DNA from replication and transcription.
First, CHD4 can be recruited to sites of DNA damage by binding to poly(ADP-ribosyl)ated proteins, including PARP1 [poly(ADP-ribose) polymerase 1] [ 38].
Classic platinum anticancer drugs including cisplatin cause DNA damages by binding to DNA therefore creating inter- or intra-strand cross links, and, finally, leading to apoptosis.
Like fibrinogen, haptoglobin is an acute phase protein that inhibits hemoglobin-induced oxidative tissue damage by binding to free hemoglobin (110).
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